|
KMID : 0605620210280010001
|
|
Journal of Korean Society of Biological Psychiatry
2021 Volume.28 No. 1 p.1 ~ p.6
|
|
|
Current Pharmacogenetics in Psychiatry
|
|
Kim Il-Bin
Lee Yu-Sang
|
|
|
Abstract
|
|
|
|
Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry
|
|
|
KEYWORD
|
|
|
Pharmacogenetics, Drug-metabolizing enzyme, CYP450, Genotyping, Psychiatry
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|